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- Title
Furosemide and albumin for diuresis of edema (FADE): a study protocol for a randomized controlled trial.
- Authors
Oczkowski, Simon J W; Mazzetti, Ian; Meade, Maureen O; Hamielec, Cindy
- Abstract
Fluid retention is a common complication of critical illness. It typically results from large-volume fluid infusions during acute resuscitation and is worsened by hypoalbuminemia. Recognized as edema, fluid retention is important for its association with delayed weaning and increased mortality. The standard treatment is the administration of diuretics, with or without albumin. We hypothesize that intravenous 25% albumin plus furosemide, by comparison with furosemide alone, improves diuresis, oxygenation, and hemodynamic stability in the deresuscitation of critically ill, hypoalbuminemic patients. We propose a pilot study to determine the feasibility of a trial to investigate this hypothesis.
- Publication
Trials, 2014, Vol 15, p222
- ISSN
1745-6215
- Publication type
Journal Article
- DOI
10.1186/1745-6215-15-222