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- Title
Association of trial registration with the results and conclusions of published trials of new oncology drugs.
- Authors
Rasmussen, Nicolas; Lee, Kirby; Bero, Lisa
- Abstract
Registration of clinical trials has been introduced largely to reduce bias toward statistically significant results in the trial literature. Doubts remain about whether advance registration alone is an adequate measure to reduce selective publication, selective outcome reporting, and biased design. One of the first areas of medicine in which registration was widely adopted was oncology, although the bulk of registered oncology trials remain unpublished. The net influence of registration on the literature remains untested. This study compares the prevalence of favorable results and conclusions among published reports of registered and unregistered randomized controlled trials of new oncology drugs.
- Publication
Trials, 2009, Vol 10, p116
- ISSN
1745-6215
- Publication type
Journal Article
- DOI
10.1186/1745-6215-10-116