We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90.
- Authors
Breuer, Denitra; Kotelkin, Alexander; Ammosova, Tatiana; Kumari, Namita; Ivanov, Andrey; Ilatovskiy, Andrey V; Beullens, Monique; Roane, Philip R; Bollen, Mathieu; Petukhov, Michael G; Kashanchi, Fatah; Nekhai, Sergei
- Abstract
HIV-1 transcription is activated by the viral Tat protein that recruits host positive transcription elongation factor-b (P-TEFb) containing CDK9/cyclin T1 to the HIV-1 promoter. P-TEFb in the cells exists as a lower molecular weight CDK9/cyclin T1 dimer and a high molecular weight complex of 7SK RNA, CDK9/cyclin T1, HEXIM1 dimer and several additional proteins. Our previous studies implicated CDK2 in HIV-1 transcription regulation. We also found that inhibition of CDK2 by iron chelators leads to the inhibition of CDK9 activity, suggesting a functional link between CDK2 and CDK9. Here, we investigate whether CDK2 phosphorylates CDK9 and regulates its activity.
- Publication
Retrovirology, 2012, Vol 9, p94
- ISSN
1742-4690
- Publication type
Journal Article
- DOI
10.1186/1742-4690-9-94