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- Title
Interplay between HIV entry and transportin-SR2 dependency.
- Authors
Thys, Wannes; De Houwer, Stéphanie; Demeulemeester, Jonas; Taltynov, Oliver; Vancraenenbroeck, Renée; Gérard, Melanie; De Rijck, Jan; Gijsbers, Rik; Christ, Frauke; Debyser, Zeger
- Abstract
Transportin-SR2 (TRN-SR2, TNPO3, transportin 3) was previously identified as an interaction partner of human immunodeficiency virus type 1 (HIV-1) integrase and functions as a nuclear import factor of HIV-1. A possible role of capsid in transportin-SR2-mediated nuclear import was recently suggested by the findings that a chimeric HIV virus, carrying the murine leukemia virus (MLV) capsid and matrix proteins, displayed a transportin-SR2 independent phenotype, and that the HIV-1 N74D capsid mutant proved insensitive to transportin-SR2 knockdown.
- Publication
Retrovirology, 2011, Vol 8, p7
- ISSN
1742-4690
- Publication type
Journal Article
- DOI
10.1186/1742-4690-8-7