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- Title
Extensive complement-dependent enhancement of HIV-1 by autologous non-neutralising antibodies at early stages of infection.
- Authors
Willey, Suzanne; Aasa-Chapman, Marlén M I; O'Farrell, Stephen; Pellegrino, Pierre; Williams, Ian; Weiss, Robin A; Neil, Stuart J D
- Abstract
Non-neutralising antibodies to the envelope glycoprotein are elicited during acute HIV-1 infection and are abundant throughout the course of disease progression. Although these antibodies appear to have negligible effects on HIV-1 infection when assayed in standard neutralisation assays, they have the potential to exert either inhibitory or enhancing effects through interactions with complement and/or Fc receptors. Here we report that non-neutralising antibodies produced early in response to HIV-1 infection can enhance viral infectivity.
- Publication
Retrovirology, 2011, Vol 8, p16
- ISSN
1742-4690
- Publication type
Journal Article
- DOI
10.1186/1742-4690-8-16