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- Title
Biophysical analysis of HTLV-1 particles reveals novel insights into particle morphology and Gag stochiometry.
- Authors
Grigsby, Iwen F; Zhang, Wei; Johnson, Jolene L; Fogarty, Keir H; Chen, Yan; Rawson, Jonathan M; Crosby, Aaron J; Mueller, Joachim D; Mansky, Louis M
- Abstract
Human T-lymphotropic virus type 1 (HTLV-1) is an important human retrovirus that is a cause of adult T-cell leukemia/lymphoma. While an important human pathogen, the details regarding virus replication cycle, including the nature of HTLV-1 particles, remain largely unknown due to the difficulties in propagating the virus in tissue culture. In this study, we created a codon-optimized HTLV-1 Gag fused to an EYFP reporter as a model system to quantitatively analyze HTLV-1 particles released from producer cells.
- Publication
Retrovirology, 2010, Vol 7, p75
- ISSN
1742-4690
- Publication type
Journal Article
- DOI
10.1186/1742-4690-7-75