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- Title
Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2.
- Authors
Chaipan, Chawaree; Steffen, Imke; Tsegaye, Theodros Solomon; Bertram, Stephanie; Glowacka, Ilona; Kato, Yukinari; Schmökel, Jan; Münch, Jan; Simmons, Graham; Gerardy-Schahn, Rita; Pöhlmann, Stefan
- Abstract
Platelets are associated with HIV in the blood of infected individuals and might modulate viral dissemination, particularly if the virus is directly transmitted into the bloodstream. The C-type lectin DC-SIGN and the novel HIV attachment factor CLEC-2 are expressed by platelets and facilitate HIV transmission from platelets to T-cells. Here, we studied the molecular mechanisms behind CLEC-2-mediated HIV-1 transmission.
- Publication
Retrovirology, 2010, Vol 7, p47
- ISSN
1742-4690
- Publication type
Journal Article
- DOI
10.1186/1742-4690-7-47