We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Experimental depletion of CD8+ cells in acutely SIVagm-infected African Green Monkeys results in increased viral replication.
- Authors
Gaufin, Thaidra; Ribeiro, Ruy M; Gautam, Rajeev; Dufour, Jason; Mandell, Daniel; Apetrei, Cristian; Pandrea, Ivona
- Abstract
In vivo CD8+ cell depletions in pathogenic SIV infections identified a key role for cellular immunity in controlling viral load (VL) and disease progression. However, similar studies gave discordant results in chronically-infected SMs, leading some authors to propose that in natural hosts, SIV replication is independent of cellular immunity. To assess the role of cellular immune responses in the control of SIV replication in natural hosts, we investigated the impact of CD8+ cell depletion during acute SIV infection in AGMs.
- Publication
Retrovirology, 2010, Vol 7, p42
- ISSN
1742-4690
- Publication type
Journal Article
- DOI
10.1186/1742-4690-7-42