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- Title
Live cell visualization of the interactions between HIV-1 Gag and the cellular RNA-binding protein Staufen1.
- Authors
Milev, Miroslav P; Brown, Chris M; Mouland, Andrew J
- Abstract
Human immunodeficiency virus type 1 (HIV-1) uses cellular proteins and machinery to ensure transmission to uninfected cells. Although the host proteins involved in the transport of viral components toward the plasma membrane have been investigated, the dynamics of this process remain incompletely described. Previously we showed that the double-stranded (ds)RNA-binding protein, Staufen1 is found in the HIV-1 ribonucleoprotein (RNP) that contains the HIV-1 genomic RNA (vRNA), Gag and other host RNA-binding proteins in HIV-1-producing cells. Staufen1 interacts with the nucleocapsid domain (NC) domain of Gag and regulates Gag multimerization on membranes thereby modulating HIV-1 assembly. The formation of the HIV-1 RNP is dynamic and likely central to the fate of the vRNA during the late phase of the HIV-1 replication cycle.
- Publication
Retrovirology, 2010, Vol 7, p41
- ISSN
1742-4690
- Publication type
Journal Article
- DOI
10.1186/1742-4690-7-41