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- Title
Tax gene expression and cell cycling but not cell death are selected during HTLV-1 infection in vivo.
- Authors
Zane, Linda; Sibon, David; Jeannin, Lionel; Zandecki, Marc; Delfau-Larue, Marie-Hélène; Gessain, Antoine; Gout, Olivier; Pinatel, Christiane; Lançon, Agnès; Mortreux, Franck; Wattel, Eric
- Abstract
Adult T cell leukemia results from the malignant transformation of a CD4+ lymphoid clone carrying an integrated HTLV-1 provirus that has undergone several oncogenic events over a 30-60 year period of persistent clonal expansion. Both CD4+ and CD8+ lymphocytes are infected in vivo; their expansion relies on CD4+ cell cycling and on the prevention of CD8+ cell death. Cloned infected CD4+ but not CD8+ T cells from patients without malignancy also add up nuclear and mitotic defects typical of genetic instability related to the expression of the virus-encoded oncogene tax. HTLV-1 expression is cancer-prone in vitro, but in vivo numerous selection forces act to maintain T cell homeostasis and are possibly involved in clonal selection.
- Publication
Retrovirology, 2010, Vol 7, p17
- ISSN
1742-4690
- Publication type
Journal Article
- DOI
10.1186/1742-4690-7-17