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- Title
Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients.
- Authors
Hohn, Oliver; Krause, Hans; Barbarotto, Pia; Niederstadt, Lars; Beimforde, Nadine; Denner, Joachim; Miller, Kurt; Kurth, Reinhard; Bannert, Norbert
- Abstract
A novel gammaretrovirus named xenotropic murine leukemia virus-related virus (XMRV) has been recently identified and found to have a prevalence of 40% in prostate tumor samples from American patients carrying a homozygous R462Q mutation in the RNaseL gene. This mutation impairs the function of the innate antiviral type I interferon pathway and is a known susceptibility factor for prostate cancer. Here, we attempt to measure the prevalence of XMRV in prostate cancer cases in Germany and determine whether an analogous association with the R462Q polymorphism exists.
- Publication
Retrovirology, 2009, Vol 6, p92
- ISSN
1742-4690
- Publication type
Journal Article
- DOI
10.1186/1742-4690-6-92