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- Title
Analysis of transcribed human endogenous retrovirus W env loci clarifies the origin of multiple sclerosis-associated retrovirus env sequences.
- Authors
Laufer, Georg; Mayer, Jens; Mueller, Benedikt F; Mueller-Lantzsch, Nikolaus; Ruprecht, Klemens
- Abstract
Multiple sclerosis-associated retrovirus (MSRV) RNA sequences have been detected in patients with multiple sclerosis (MS) and are related to the multi-copy human endogenous retrovirus family type W (HERV-W). Only one HERV-W locus (ERVWE1) codes for a complete HERV-W Env protein (Syncytin-1). Syncytin-1 and the putative MSRV Env protein have been involved in the pathogenesis of MS. The origin of MSRV and its precise relation to HERV-W were hitherto unknown.
- Publication
Retrovirology, 2009, Vol 6, p37
- ISSN
1742-4690
- Publication type
Journal Article
- DOI
10.1186/1742-4690-6-37