We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Dynamics of viral replication in blood and lymphoid tissues during SIVmac251 infection of macaques.
- Authors
Mannioui, Abdelkrim; Bourry, Olivier; Sellier, Pierre; Delache, Benoit; Brochard, Patricia; Andrieu, Thibault; Vaslin, Bruno; Karlsson, Ingrid; Roques, Pierre; Le Grand, Roger
- Abstract
Extensive studies of primary infection are crucial to our understanding of the course of HIV disease. In SIV-infected macaques, a model closely mimicking HIV pathogenesis, we used a combination of three markers -- viral RNA, 2LTR circles and viral DNA -- to evaluate viral replication and dissemination simultaneously in blood, secondary lymphoid tissues, and the gut during primary and chronic infections. Subsequent viral compartmentalization in the main target cells of the virus in peripheral blood during the chronic phase of infection was evaluated by cell sorting and viral quantification with the three markers studied.
- Publication
Retrovirology, 2009, Vol 6, p106
- ISSN
1742-4690
- Publication type
Journal Article
- DOI
10.1186/1742-4690-6-106