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- Title
The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcription.
- Authors
Vardabasso, Chiara; Manganaro, Lara; Lusic, Marina; Marcello, Alessandro; Giacca, Mauro
- Abstract
Despite the large amount of data available on the molecular mechanisms that regulate HIV-1 transcription, crucial information is still lacking about the interplay between chromatin conformation and the events that regulate initiation and elongation of viral transcription. During transcriptional activation, histone acetyltransferases and ATP-dependent chromatin remodeling complexes cooperate with histone chaperones in altering chromatin structure. In particular, human Nucleosome Assembly Protein-1 (hNAP-1) is known to act as a histone chaperone that shuttles histones H2A/H2B into the nucleus, assembles nucleosomes and promotes chromatin fluidity, thereby affecting transcription of several cellular genes.
- Publication
Retrovirology, 2008, Vol 5, p8
- ISSN
1742-4690
- Publication type
Journal Article
- DOI
10.1186/1742-4690-5-8