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- Title
Evolution of DC-SIGN use revealed by fitness studies of R5 HIV-1 variants emerging during AIDS progression.
- Authors
Borggren, Marie; Repits, Johanna; Kuylenstierna, Carlotta; Sterjovski, Jasminka; Churchill, Melissa J; Purcell, Damian F J; Karlsson, Anders; Albert, Jan; Gorry, Paul R; Jansson, Marianne
- Abstract
At early stages of infection CCR5 is the predominant HIV-1 coreceptor, but in approximately 50% of those infected CXCR4-using viruses emerge with disease progression. This coreceptor switch is correlated with an accelerated progression. However, those that maintain virus exclusively restricted to CCR5 (R5) also develop AIDS. We have previously reported that R5 variants in these "non-switch virus" patients evolve during disease progression towards a more replicative phenotype exhibiting altered CCR5 coreceptor interactions. DC-SIGN is a C-type lectin expressed by dendritic cells that HIV-1 may bind and utilize for enhanced infection of T cells in trans. To further explore the evolution of the R5 phenotype we analyzed sequential R5 isolates obtained before and after AIDS onset, i.e. at the chronic stage and during end-stage disease, with regard to efficiency of DC-SIGN use in trans-infections.
- Publication
Retrovirology, 2008, Vol 5, p28
- ISSN
1742-4690
- Publication type
Journal Article
- DOI
10.1186/1742-4690-5-28