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- Title
Retroviral activation of the mir-106a microRNA cistron in T lymphoma.
- Authors
Lum, Amy M; Wang, Bruce B; Li, Lauri; Channa, Namitha; Bartha, Gabor; Wabl, Matthias
- Abstract
Retroviral insertion into a host genome is a powerful tool not only for the discovery of cancer genes, but also for the discovery of potential oncogenic noncoding RNAs. In a large-scale mouse T lymphocyte tumor screen we found a high density of integrations upstream of the mir-106a microRNA cistron. In tumors containing an integration, the primary transcript encoding the mir-106a cistron was overexpressed five to 20-fold compared with that of control tumors; concomitantly, the mature mir-106a and mir-363 microRNAs were highly overexpressed as well. These findings suggest the mir-106a cistron plays an important role in T cell tumorigenesis.
- Publication
Retrovirology, 2007, Vol 4, p5
- ISSN
1742-4690
- Publication type
Journal Article
- DOI
10.1186/1742-4690-4-5