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- Title
Inactivation of HIV-1 in breast milk by treatment with the alkyl sulfate microbicide sodium dodecyl sulfate (SDS).
- Authors
Urdaneta, Sandra; Wigdahl, Brian; Neely, Elizabeth B; Berlin, Cheston M, Jr; Schengrund, Cara-Lynne; Lin, Hung-Mo; Howett, Mary K
- Abstract
Reducing transmission of HIV-1 through breast milk is needed to help decrease the burden of pediatric HIV/AIDS in society. We have previously reported that alkyl sulfates (i.e., sodium dodecyl sulfate, SDS) are microbicidal against HIV-1 at low concentrations, are biodegradable, have little/no toxicity and are inexpensive. Therefore, they may be used for treatment of HIV-1 infected breast milk. In this report, human milk was artificially infected by adding to it HIV-1 (cell-free or cell-associated) and treated with <or=1% SDS (<or=10 mg/ml). Microbicidal treatment was at 37 degrees C or room temperature for 10 min. SDS removal was performed with a commercially available resin. Infectivity of HIV-1 and HIV-1 load in breast milk were determined after treatment.
- Publication
Retrovirology, 2005, Vol 2, p28
- ISSN
1742-4690
- Publication type
Journal Article
- DOI
10.1186/1742-4690-2-28