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- Title
A murine leukemia virus with Cre-LoxP excisible coding sequences allowing superinfection, transgene delivery, and generation of host genomic deletions.
- Authors
Wang, Clifford L; Hodgson, J Graeme; Malek, Tiffany; Pedersen, Finn Skou; Wabl, Matthias
- Abstract
To generate a replication-competent retrovirus that could be conditionally inactivated, we flanked the viral genes of the Akv murine leukemia virus with LoxP sites. This provirus can delete its envelope gene by LoxP/Cre mediated recombination and thereby allow superinfection of Cre recombinase expressing cells.
- Publication
Retrovirology, 2004, Vol 1, p5
- ISSN
1742-4690
- Publication type
Journal Article
- DOI
10.1186/1742-4690-1-5