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- Title
Eotaxin and FGF enhance signaling through an extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic esophagitis.
- Authors
Huang, Jennifer J; Joh, Jae Won; Fuentebella, Judy; Patel, Anup; Nguyen, Tammie; Seki, Scott; Hoyte, Lisa; Reshamwala, Neha; Nguyen, Christine; Quiros, Anthony; Bass, Dorsey; Sibley, Eric; Berquist, William; Cox, Kenneth; Kerner, John; Nadeau, Kari C
- Abstract
Eosinophilic esophagitis (EoE) is characterized by the inflammation of the esophagus and the infiltration of eosinophils into the esophagus, leading to symptoms such as dysphagia and stricture formation. Systemic immune indicators like eotaxin and fibroblast growth factor were evaluated for possible synergistic pathological effects. Moreover, blood cells, local tissue, and plasma from EoE and control subjects were studied to determine if the localized disease was associated with a systemic effect that correlated with presence of EoE disease.
- Publication
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2010, Vol 6, Issue 1, p25
- ISSN
1710-1492
- Publication type
Journal Article
- DOI
10.1186/1710-1492-6-25