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- Title
Stress and childhood asthma risk: overlapping evidence from animal studies and epidemiologic research.
- Authors
Wright, Rosalind J
- Abstract
: Rapidly expanding evidence increasingly strengthens the evidence linking psychological factors to asthma and allergy expression. Parallel studies in animals and humans demonstrating the influence of prenatal maternal stress and early caregiving experiences on the disrupted regulation of defensive biological systems [eg, sympathetic and adrenomedullary (SAM) system and the hypothalamicpituitary-adrenocortical (HPA) axis] provide strong proof of concept for this line of research. The consequent altered neuroimmune responses may influence the expression of immune-mediated disorders such as asthma as well as enhance an individual's susceptibility to other environmental factors that may also contribute to asthma risk.
- Publication
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2008, Vol 4, Issue 1, p29
- ISSN
1710-1492
- Publication type
Journal Article
- DOI
10.1186/1710-1492-4-1-29