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- Title
Extracellular volume fraction mapping in the myocardium, part 1: evaluation of an automated method.
- Authors
Kellman, Peter; Wilson, Joel R; Xue, Hui; Ugander, Martin; Arai, Andrew E
- Abstract
Disturbances in the myocardial extracellular volume fraction (ECV), such as diffuse or focal myocardial fibrosis or edema, are hallmarks of heart disease. Diffuse ECV changes are difficult to assess or quantify with cardiovascular magnetic resonance (CMR) using conventional late gadolinium enhancement (LGE), or pre- or post-contrast T1-mapping alone. ECV measurement circumvents factors that confound T1-weighted images or T1-maps, and has been shown to correlate well with diffuse myocardial fibrosis. The goal of this study was to develop and evaluate an automated method for producing a pixel-wise map of ECV that would be adequately robust for clinical work flow.
- Publication
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2012, Vol 14, p63
- ISSN
1532-429X
- Publication type
Journal Article
- DOI
10.1186/1532-429X-14-63