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- Title
Estimating myocardial perfusion from dynamic contrast-enhanced CMR with a model-independent deconvolution method.
- Authors
Pack, Nathan A; DiBella, Edward V R; Rust, Thomas C; Kadrmas, Dan J; McGann, Christopher J; Butterfield, Regan; Christian, Paul E; Hoffman, John M
- Abstract
Model-independent analysis with B-spline regularization has been used to quantify myocardial blood flow (perfusion) in dynamic contrast-enhanced cardiovascular magnetic resonance (CMR) studies. However, the model-independent approach has not been extensively evaluated to determine how the contrast-to-noise ratio between blood and tissue enhancement affects estimates of myocardial perfusion and the degree to which the regularization is dependent on the noise in the measured enhancement data. We investigated these questions with a model-independent analysis method that uses iterative minimization and a temporal smoothness regularizer. Perfusion estimates using this method were compared to results from dynamic 13N-ammonia PET.
- Publication
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2008, Vol 10, p52
- ISSN
1532-429X
- Publication type
Journal Article
- DOI
10.1186/1532-429X-10-52