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- Title
The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling.
- Authors
Jünger, Martin A; Rintelen, Felix; Stocker, Hugo; Wasserman, Jonathan D; Végh, Mátyás; Radimerski, Thomas; Greenberg, Michael E; Hafen, Ernst
- Abstract
Forkhead transcription factors belonging to the FOXO subfamily are negatively regulated by protein kinase B (PKB) in response to signaling by insulin and insulin-like growth factor in Caenorhabditis elegans and mammals. In Drosophila, the insulin-signaling pathway regulates the size of cells, organs, and the entire body in response to nutrient availability, by controlling both cell size and cell number. In this study, we present a genetic characterization of dFOXO, the only Drosophila FOXO ortholog.
- Publication
Journal of biology, 2003, Vol 2, Issue 3, p20
- ISSN
1475-4924
- Publication type
Journal Article
- DOI
10.1186/1475-4924-2-20