We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Identification of conserved regulatory elements by comparative genome analysis.
- Authors
Lenhard, Boris; Sandelin, Albin; Mendoza, Luis; Engström, Pär; Jareborg, Niclas; Wasserman, Wyeth W
- Abstract
For genes that have been successfully delineated within the human genome sequence, most regulatory sequences remain to be elucidated. The annotation and interpretation process requires additional data resources and significant improvements in computational methods for the detection of regulatory regions. One approach of growing popularity is based on the preferential conservation of functional sequences over the course of evolution by selective pressure, termed 'phylogenetic footprinting'. Mutations are more likely to be disruptive if they appear in functional sites, resulting in a measurable difference in evolution rates between functional and non-functional genomic segments.
- Publication
Journal of biology, 2003, Vol 2, Issue 2, p13
- ISSN
1475-4924
- Publication type
Journal Article
- DOI
10.1186/1475-4924-2-13