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- Title
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.
- Authors
Frank-Kamenetsky, Maria; Zhang, Xiaoyan M; Bottega, Steve; Guicherit, Oivin; Wichterle, Hynek; Dudek, Henryk; Bumcrot, David; Wang, Frank Y; Jones, Simon; Shulok, Janine; Rubin, Lee L; Porter, Jeffery A
- Abstract
The Hedgehog (Hh) signaling pathway is vital to animal development as it mediates the differentiation of multiple cell types during embryogenesis. In adults, Hh signaling can be activated to facilitate tissue maintenance and repair. Moreover, stimulation of the Hh pathway has shown therapeutic efficacy in models of neuropathy. The underlying mechanisms of Hh signal transduction remain obscure, however: little is known about the communication between the pathway suppressor Patched (Ptc), a multipass transmembrane protein that directly binds Hh, and the pathway activator Smoothened (Smo), a protein that is related to G-protein-coupled receptors and is capable of constitutive activation in the absence of Ptc.
- Publication
Journal of biology, 2002, Vol 1, Issue 2, p10
- ISSN
1475-4924
- Publication type
Journal Article
- DOI
10.1186/1475-4924-1-10