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- Title
Study protocol: a randomised controlled trial investigating the effect of exercise training on peripheral blood gene expression in patients with stable angina.
- Authors
Bourke, Liam; Tew, Garry A; Milo, Marta; Crossman, David C; Saxton, John M; Chico, Timothy J A
- Abstract
Exercise training has been shown to reduce angina and promote collateral vessel development in patients with coronary artery disease. However, the mechanism whereby exercise exerts these beneficial effects is unclear. There has been increasing interest in the use of whole genome peripheral blood gene expression in a wide range of conditions to attempt to identify both novel mechanisms of disease and transcriptional biomarkers. This protocol describes a study in which we will assess the effect of a structured exercise programme on peripheral blood gene expression in patients with stable angina, and correlate this with changes in angina level, anxiety, depression, and exercise capacity.
- Publication
BMC public health, 2010, Vol 10, p620
- ISSN
1471-2458
- Publication type
Journal Article
- DOI
10.1186/1471-2458-10-620