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- Title
Single photon emission computed tomography (SPECT) of anxiety disorders before and after treatment with citalopram.
- Authors
Carey, Paul D; Warwick, James; Niehaus, Dana J H; van der Linden, Geoffrey; van Heerden, Barend B; Harvey, Brian H; Seedat, Soraya; Stein, Dan J
- Abstract
Several studies have now examined the effects of selective serotonin reuptake inhibitor (SSRI) treatment on brain function in a variety of anxiety disorders including obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), and social anxiety disorder (social phobia) (SAD). Regional changes in cerebral perfusion following SSRI treatment have been shown for all three disorders. The orbitofrontal cortex (OFC) (OCD), caudate (OCD), medial pre-frontal/cingulate (OCD, SAD, PTSD), temporal (OCD, SAD, PTSD) and, thalamic regions (OCD, SAD) are some of those implicated. Some data also suggests that higher perfusion pre-treatment in the anterior cingulate (PTSD), OFC, caudate (OCD) and antero-lateral temporal region (SAD) predicts subsequent treatment response. This paper further examines the notion of overlap in the neurocircuitry of treatment and indeed treatment response across anxiety disorders with SSRI treatment.
- Publication
BMC psychiatry, 2004, Vol 4, p30
- ISSN
1471-244X
- Publication type
Journal Article
- DOI
10.1186/1471-244X-4-30