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- Title
Glucocorticoid receptor mRNA and protein isoform alterations in the orbitofrontal cortex in schizophrenia and bipolar disorder.
- Authors
Sinclair, Duncan; Webster, Maree J; Fullerton, Janice M; Weickert, Cynthia Shannon
- Abstract
The orbitofrontal cortex (OFC) may play a role in the pathogenesis of psychiatric illnesses such as bipolar disorder and schizophrenia, in which hypothalamic-pituitary-adrenal (HPA) axis abnormalities are observed and stress has been implicated. A critical component of the HPA axis which mediates cellular stress responses in the OFC, and has been implicated in psychiatric illness, is the glucocorticoid receptor (GR).
- Publication
BMC psychiatry, 2012, Vol 12, p84
- ISSN
1471-244X
- Publication type
Journal Article
- DOI
10.1186/1471-244X-12-84