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- Title
Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states.
- Authors
Sarver, Aaron L; French, Amy J; Borralho, Pedro M; Thayanithy, Venugopal; Oberg, Ann L; Silverstein, Kevin A T; Morlan, Bruce W; Riska, Shaun M; Boardman, Lisa A; Cunningham, Julie M; Subramanian, Subbaya; Wang, Liang; Smyrk, Tom C; Rodrigues, Cecilia M P; Thibodeau, Stephen N; Steer, Clifford J
- Abstract
Colon cancer arises from the accumulation of multiple genetic and epigenetic alterations to normal colonic tissue. microRNAs (miRNAs) are small, non-coding regulatory RNAs that post-transcriptionally regulate gene expression. Differential miRNA expression in cancer versus normal tissue is a common event and may be pivotal for tumor onset and progression.
- Publication
BMC cancer, 2009, Vol 9, p401
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-9-401