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- Title
Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer.
- Authors
Veeck, Jürgen; Wild, Peter J; Fuchs, Thomas; Schüffler, Peter J; Hartmann, Arndt; Knüchel, Ruth; Dahl, Edgar
- Abstract
Secreted Wnt signaling antagonists have recently been described as frequent targets of epigenetic inactivation in human tumor entities. Since gene silencing of certain Wnt antagonists was found to be correlated with adverse patient survival in cancer, we aimed at investigating a potential prognostic impact of the two Wnt antagonizing molecules WIF1 and DKK3 in breast cancer, which are frequently silenced by promoter methylation in this disease.
- Publication
BMC cancer, 2009, Vol 9, p217
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-9-217