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- Title
Tissue micro array analysis of ganglioside N-glycolyl GM3 expression and signal transducer and activator of transcription (STAT)-3 activation in relation to dendritic cell infiltration and microvessel density in non-small cell lung cancer.
- Authors
van Cruijsen, Hester; Ruiz, Mariëlle Gallegos; van der Valk, Paul; de Gruijl, Tanja D; Giaccone, Giuseppe
- Abstract
Tumor immune escape and angiogenesis contribute to tumor progression, and gangliosides and activation of signal transducer and activator of transcription (STAT)-3 are implicated in these processes. As both are considered as novel therapeutic targets, we assessed the possible association of ganglioside GM3 expression and STAT3 activation with suppression of dendritic cell (DC) activation and angiogenesis in non-small cell lung cancer (NSCLC).
- Publication
BMC cancer, 2009, Vol 9, p180
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-9-180