We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities.
- Authors
Press, Joshua Z; De Luca, Alessandro; Boyd, Niki; Young, Sean; Troussard, Armelle; Ridge, Yolanda; Kaurah, Pardeep; Kalloger, Steve E; Blood, Katherine A; Smith, Margaret; Spellman, Paul T; Wang, Yuker; Miller, Dianne M; Horsman, Doug; Faham, Malek; Gilks, C Blake; Gray, Joe; Huntsman, David G
- Abstract
Subclassification of ovarian carcinomas can be used to guide treatment and determine prognosis. Germline and somatic mutations, loss of heterozygosity (LOH), and epigenetic events such as promoter hypermethylation can lead to decreased expression of BRCA1/2 in ovarian cancers. The mechanism of BRCA1/2 loss is a potential method of subclassifying high grade serous carcinomas.
- Publication
BMC cancer, 2008, Vol 8, p17
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-8-17