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- Title
The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors.
- Authors
Winter, Sherry L; Bosnoyan-Collins, Lucine; Pinnaduwage, Dushanthi; Andrulis, Irene L
- Abstract
The breast cancer susceptibility gene, BRCA1, is implicated in multiple cellular processes including DNA repair, the transactivation of genes, and the ubiquitination of proteins; however its precise functions remain to be fully understood. Identification and characterization of BRCA1 protein interactions may help to further elucidate the function and regulation of BRCA1. Additionally, detection of changes in the expression levels of BRCA1 and its interacting proteins in primary human breast tumors may further illuminate their role in the development of breast cancer.
- Publication
BMC cancer, 2007, Vol 7, p85
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-7-85