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- Title
Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process.
- Authors
Chandran, Uma R; Ma, Changqing; Dhir, Rajiv; Bisceglia, Michelle; Lyons-Weiler, Maureen; Liang, Wenjing; Michalopoulos, George; Becich, Michael; Monzon, Federico A
- Abstract
Prostate cancer is characterized by heterogeneity in the clinical course that often does not correlate with morphologic features of the tumor. Metastasis reflects the most adverse outcome of prostate cancer, and to date there are no reliable morphologic features or serum biomarkers that can reliably predict which patients are at higher risk of developing metastatic disease. Understanding the differences in the biology of metastatic and organ confined primary tumors is essential for developing new prognostic markers and therapeutic targets.
- Publication
BMC cancer, 2007, Vol 7, p64
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-7-64