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Title
TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study.
Authors
Cox, David G; Penney, Kathryn; Guo, Qun; Hankinson, Susan E; Hunter, David J
Abstract
Transforming growth factor beta 1 (TGFB1) forms a signaling complex with transforming growth factor beta receptors 1 and 2 and has been described as both a tumor suppressor and tumor promoter. Single nucleotide polymorphisms in TGFB1 and a microsatellite in TGFBR1 have been investigated for association with risk of breast cancer, with conflicting results.