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- Title
Reevaluation of the 22-1-1 antibody and its putative antigen, EBAG9/RCAS1, as a tumor marker.
- Authors
Reimer, Tatiana A; Anagnostopoulos, Ioannis; Erdmann, Bettina; Lehmann, Insa; Stein, Harald; Daniel, Peter; Dörken, Bernd; Rehm, Armin
- Abstract
Tumor-associated antigens are appreciated as diagnostic markers, but they have also prompted tremendous efforts to develop tumor-specific immunotherapy. A previously cloned tumor-associated antigen, EBAG9, was initially defined by reactivity with the monoclonal antibody 22-1-1. Functionally, the EBAG9-encoded gene-product was believed to induce apoptosis in activated immune cells. However, using a cell-biological approach we identified EBAG9 as a Golgi-resident modulator of O-linked glycan expression, the latter product was then recognized by the 22-1-1 antibody. Secondly, EBAG9 expression was found physiologically in all murine tissues examined. This raised the question if EBAG9 is tumor-specific and mediates apoptosis itself or through O-linked glycans generated, among them the cognate 22-1-1 antigen Tn.
- Publication
BMC cancer, 2005, Vol 5, p47
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-5-47