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- Title
Differences in gene expression in prostate cancer, normal appearing prostate tissue adjacent to cancer and prostate tissue from cancer free organ donors.
- Authors
Chandran, Uma R; Dhir, Rajiv; Ma, Changqing; Michalopoulos, George; Becich, Michael; Gilbertson, John
- Abstract
Typical high throughput microarrays experiments compare gene expression across two specimen classes - an experimental class and baseline (or comparison) class. The choice of specimen classes is a major factor in the differential gene expression patterns revealed by these experiments. In most studies of prostate cancer, histologically malignant tissue is chosen as the experimental class while normal appearing prostate tissue adjacent to the tumor (adjacent normal) is chosen as the baseline against which comparison is made. However, normal appearing prostate tissue from tumor free organ donors represents an alterative source of baseline tissue for differential expression studies.
- Publication
BMC cancer, 2005, Vol 5, p45
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-5-45