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- Title
Role of the p53/p21 system in the response of human colon carcinoma cells to Doxorubicin.
- Authors
Ravizza, Raffaella; Gariboldi, Marzia B; Passarelli, Laura; Monti, Elena
- Abstract
Colon adenocarcinomas are refractory to a number of widely used anticancer agents. Multifactorial mechanisms have been implicated in this intrinsically resistant phenotype, including deregulation of cell death pathways. In this regard, the p53 protein has a well established role in the control of tumor cell response to DNA damaging agents; however, the relationship between p53-driven genes and drug sensitivity remains controversial. The present study investigates the role of the p53/p21 system in the response of human colon carcinoma cells to treatment with the cytotoxic agent doxorubicin (DOX) and the possibility to modify the therapeutic index of DOX by modulation of p53 and/or p21 protein levels.
- Publication
BMC cancer, 2004, Vol 4, p92
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-4-92