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- Title
Allelotypes of lung adenocarcinomas featuring ALK fusion demonstrate fewer onco- and suppressor gene changes.
- Authors
Ninomiya, Hironori; Kato, Motohiro; Sanada, Masashi; Takeuchi, Kengo; Inamura, Kentaro; Motoi, Noriko; Nagano, Hiroko; Nomura, Kimie; Sakao, Yukinori; Okumura, Sakae; Mano, Hiroyuki; Ogawa, Seishi; Ishikawa, Yuichi
- Abstract
A subset of lung adenocarcinomas harboring an EML4-ALK fusion gene resulting in dominant oncogenic activity has emerged as a target for specific therapy. EML4-ALK fusion confers a characteristic histology and is detected more frequently in never or light smokers and younger patients.
- Publication
BMC cancer, 2013, Vol 13, p8
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-13-8