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- Title
N-benzyladriamycin-14-valerate (AD 198) exhibits potent anti-tumor activity on TRAF3-deficient mouse B lymphoma and human multiple myeloma.
- Authors
Edwards, Shanique K E; Moore, Carissa R; Liu, Yan; Grewal, Sukhdeep; Covey, Lori R; Xie, Ping
- Abstract
TRAF3, a new tumor suppressor identified in human non-Hodgkin lymphoma (NHL) and multiple myeloma (MM), induces PKCδ nuclear translocation in B cells. The present study aimed to evaluate the therapeutic potential of two PKCδ activators, N-Benzyladriamycin-14-valerate (AD 198) and ingenol-3-angelate (PEP005), on NHL and MM.
- Publication
BMC cancer, 2013, Vol 13, p481
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-13-481