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- Title
The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients.
- Authors
Medrek, Catharina; Pontén, Fredrik; Jirström, Karin; Leandersson, Karin
- Abstract
Tumor associated macrophages (TAMs) are alternatively activated macrophages that enhance tumor progression by promoting tumor cell invasion, migration and angiogenesis. TAMs have an anti-inflammatory function resembling M2 macrophages. CD163 is regarded as a highly specific monocyte/macrophage marker for M2 macrophages. In this study we evaluated the specificity of using the M2 macrophage marker CD163 as a TAM marker and compared its prognostic value with the more frequently used pan-macrophage marker CD68. We also analyzed the prognostic value of the localization of CD163(+) and CD68(+) myeloid cells in human breast cancer.
- Publication
BMC cancer, 2012, Vol 12, p306
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-12-306