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Title
Activating mutation in MET oncogene in familial colorectal cancer.
Abstract
The article presents a study that examines the proto-oncogene and tyrosine kinase receptor, MET, genetic mutation in familial colorectal cancer (CRC). A germline non-synonymous change in the MET proto-oncogene at amino acid position affected with CRC was examined. It is given that threonine at amino acid position in the tyrosine kinase domain of MET and a change to isoleucine at this position has been shown to promote metastatic behavior.