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- Title
MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma.
- Authors
Tivnan, Amanda; Tracey, Lorraine; Buckley, Patrick G; Alcock, Leah C; Davidoff, Andrew M; Stallings, Raymond L
- Abstract
Neuroblastoma is a paediatric cancer which originates from precursor cells of the sympathetic nervous system and accounts for 15% of childhood cancer mortalities. With regards to the role of miRNAs in neuroblastoma, miR-34a, mapping to a chromosome 1p36 region that is commonly deleted, has been found to act as a tumor suppressor through targeting of numerous genes associated with cell proliferation and apoptosis.
- Publication
BMC cancer, 2011, Vol 11, p33
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-11-33