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- Title
Identification and regulation of c-Myb target genes in MCF-7 cells.
- Authors
Quintana, Anita M; Liu, Fan; O'Rourke, John P; Ness, Scott A
- Abstract
The c-Myb transcription factor regulates differentiation and proliferation in hematopoietic cells, stem cells and epithelial cells. Although oncogenic versions of c-Myb were first associated with leukemias, over expression or rearrangement of the c-myb gene is common in several types of solid tumors, including breast cancers. Expression of the c-myb gene in human breast cancer cells is dependent on estrogen stimulation, but little is known about the activities of the c-Myb protein or what genes it regulates in estrogen-stimulated cells.
- Publication
BMC cancer, 2011, Vol 11, p30
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-11-30