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- Title
Smac mimetic-derived augmentation of chemotherapeutic response in experimental pancreatic cancer.
- Authors
Awasthi, Niranjan; Kirane, Amanda; Schwarz, Margaret A; Toombs, Jason E; Brekken, Rolf A; Schwarz, Roderich E
- Abstract
Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to conventional chemotherapy, in part due to the overexpression of inhibitors of apoptosis proteins (IAPs). Smac is an endogenous IAP-antagonist, which renders synthetic Smac mimetics attractive anticancer agents. We evaluated the benefits of combining a Smac mimetic, JP1201 (JP), with conventional chemotherapy agents used for PDAC management.
- Publication
BMC cancer, 2011, Vol 11, p15
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-11-15