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- Title
Non-randomized therapy trial to determine the safety and efficacy of heavy ion radiotherapy in patients with non-resectable osteosarcoma.
- Authors
Blattmann, Claudia; Oertel, Susanne; Schulz-Ertner, Daniela; Rieken, Stefan; Haufe, Sabine; Ewerbeck, Volker; Unterberg, Andreas; Karapanagiotou-Schenkel, Irini; Combs, Stephanie E; Nikoghosyan, Anna; Bischof, Marc; Jäkel, Oliver; Huber, Peter; Kulozik, Andreas E; Debus, Jürgen
- Abstract
Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. For effective treatment, local control of the tumor is absolutely critical, because the chances of long term survival are <10% and might effectively approach zero if a complete surgical resection of the tumor is not possible. Up to date there is no curative treatment protocol for patients with non-resectable osteosarcomas, who are excluded from current osteosarcoma trials, e.g. EURAMOS1. Local photon radiotherapy has previously been used in small series and in an uncontrolled, highly individualized fashion, which, however, documented that high dose radiotherapy can, in principle, be used to achieve local control. Generally the radiation dose that is necessary for a curative approach can hardly be achieved with conventional photon radiotherapy in patients with non-resectable tumors that are usually located near radiosensitive critical organs such as the brain, the spine or the pelvis. In these cases particle Radiotherapy (proton therapy (PT)/heavy ion therapy (HIT) may offer a promising new alternative. Moreover, compared with photons, heavy ion beams provide a higher physical selectivity because of their finite depth coverage in tissue. They achieve a higher relative biological effectiveness. Phase I/II dose escalation studies of HIT in adults with non-resectable bone and soft tissue sarcomas have already shown favorable results.
- Publication
BMC cancer, 2010, Vol 10, p96
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-10-96