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- Title
Expression profiling in canine osteosarcoma: identification of biomarkers and pathways associated with outcome.
- Authors
O'Donoghue, Liza E; Ptitsyn, Andrey A; Kamstock, Debra A; Siebert, Janet; Thomas, Russell S; Duval, Dawn L
- Abstract
Osteosarcoma (OSA) spontaneously arises in the appendicular skeleton of large breed dogs and shares many physiological and molecular biological characteristics with human OSA. The standard treatment for OSA in both species is amputation or limb-sparing surgery, followed by chemotherapy. Unfortunately, OSA is an aggressive cancer with a high metastatic rate. Characterization of OSA with regard to its metastatic potential and chemotherapeutic resistance will improve both prognostic capabilities and treatment modalities.
- Publication
BMC cancer, 2010, Vol 10, p506
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-10-506