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- Title
Nuclear beta-catenin and CD44 upregulation characterize invasive cell populations in non-aggressive MCF-7 breast cancer cells.
- Authors
Uchino, Masahiro; Kojima, Hiroko; Wada, Kenta; Imada, Mika; Onoda, Fumitoshi; Satofuka, Hiroyuki; Utsugi, Takahiko; Murakami, Yasufumi
- Abstract
In breast cancer cells, the metastatic cell state is strongly correlated to epithelial-to-mesenchymal transition (EMT) and the CD44+/CD24- stem cell phenotype. However, the MCF-7 cell line, which has a luminal epithelial-like phenotype and lacks a CD44+/CD24- subpopulation, has rare cell populations with higher Matrigel invasive ability. Thus, what are the potentially important differences between invasive and non-invasive breast cancer cells, and are the differences related to EMT or CD44/CD24 expression?
- Publication
BMC cancer, 2010, Vol 10, p414
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-10-414