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- Title
Expression and activity profiles of DPP IV/CD26 and NEP/CD10 glycoproteins in the human renal cancer are tumor-type dependent.
- Authors
Varona, Adolfo; Blanco, Lorena; Perez, Itxaro; Gil, Javier; Irazusta, Jon; López, José I; Candenas, M Luz; Pinto, Francisco M; Larrinaga, Gorka
- Abstract
Cell-surface glycoproteins play critical roles in cell-to-cell recognition, signal transduction and regulation, thus being crucial in cell proliferation and cancer etiogenesis and development. DPP IV and NEP are ubiquitous glycopeptidases closely linked to tumor pathogenesis and development, and they are used as markers in some cancers. In the present study, the activity and protein and mRNA expression of these glycoproteins were analysed in a subset of clear-cell (CCRCC) and chromophobe (ChRCC) renal cell carcinomas, and in renal oncocytomas (RO).
- Publication
BMC cancer, 2010, Vol 10, p193
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-10-193