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- Title
High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology.
- Authors
Anagnostou, Valsamo K; Lowery, Frank J; Zolota, Vassiliki; Tzelepi, Vassiliki; Gopinath, Arun; Liceaga, Camil; Panagopoulos, Nikolaos; Frangia, Konstantina; Tanoue, Lynn; Boffa, Daniel; Gettinger, Scott; Detterbeck, Frank; Homer, Robert J; Dougenis, Dimitrios; Rimm, David L; Syrigos, Konstantinos N
- Abstract
Bcl-2 promotes cell survival by inhibiting adapters needed for the activation and cleavage of caspases thus blocking the proteolytic cascade that ultimately dismantles the cell. Bcl-2 has been investigated as a prognostic factor in non small cell lung cancer (NSCLC) patients with conflicting results.
- Publication
BMC cancer, 2010, Vol 10, p186
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-10-186